The star has handed over the full amount of his twenty-five thousand pound award winnings to the trust for venues, which works to preserve the Britain's grassroots live music spots.
Fender was awarded the prize on October 16 as his latest record the album was declared the top album of the last 12 months.
The musician has opted to give the cash to the MVT, in appreciation of the vital role grassroots venues had in his initial steps.
"As an artist would not have achieved this success if it weren't for all the gigs I played around the North East, and elsewhere, when I was just getting going," stated the artist. "These spaces are renowned, but they are struggling."
From early 2023 onward, over 150 of these locations have shut down – approximately 16 percent of the entire UK sector.
Recently, major artists like Pulp, Coldplay, Katy Perry and Ed Sheeran have all aided the MVT in its attempts to keep the scene afloat, by applying a modest fee to their ticket costs, which benefits smaller concert halls.
Fender also participated, raising over £100k on his live tour to assist 38 small stages across England, Scotland, and Wales.
The money supported spaces that were confronting potential shutdown due to issues caused by floods, fires and bereavements, as well as regulatory hurdles, conflicts and noise complaints.
Additional spaces received funding support in improving amenities and gear that positively impacted artists and audiences.
"The notion that revenue from concerts in large arenas helps the local stages, where it kicks off for artists like me, is just sensible," Sam Fender has stated.
Fender is not the first artist to contribute his Mercury Prize winnings to worthy causes.
Back when Pulp won the trophy in the year 1996 for their release Different Class, frontman Jarvis Cocker announced that the act would give their winnings to the organization the charity.
That year, musician she shared her award among several good causes, like the NSPCC and a Sickle Cell organization.
"And I gave a thousand pounds to the center, to their gymnastics class, because I did gymnastics when I was growing up and they lacked updated gear," Ms Dynamite told the media.
In recent years, the band donated their winnings to the youth organization that supported their band, in addition to other independent music bodies.
Also winners that year the group contributed their winnings to a multiple sclerosis charity after a close contact was diagnosed the disease.
"The victory was quite enough," remarked artist Small. "The cash was the cherry on top but we didn't need the cherry, because we had the cake. So our success impacted somebody else's life."
In the past week, the trust announced it had protected a couple of local spots in the South East, by placing them under community ownership.
The first in the city and The Croft in that location were acquired under the public acquisition scheme, which is backed by the arts council and music fans who buy "stakes" in the buildings.